@Article{MarcianoWaLoTrSoSi:2011:ThAsFi,
author = "Marciano, Fernanda Roberta and Wachesk, Cristiane da Costa and
Lobo, Anderson de Oliveira and Trava-Airoldi, Vladimir Jesus and
Soares, Cristina Pacheco and Silva, Newton Soares da",
affiliation = "Laboratorio de Nanotecnologia Biomedica (NanoBio), Universidade do
Vale do Paraiba (Univap), Av. Shishima Hifumi 2911, Sao Jose dos
Campos, SP 12244-000, Brazil and Laborato´rio de Biologia Celular
e Tecidual, Universidade do Vale do Paraiba (Univap), Av. Shishima
Hifumi 2911, Sao Jose dos Campos, SP 12244-000, Brazil and
Laboratorio de Nanotecnologia Biomedica (NanoBio), Universidade do
Vale do Paraiba (Univap), Av. Shishima Hifumi 2911, Sao Jose dos
Campos, SP 12244-000, Brazil and {Instituto Nacional de Pesquisas
Espaciais (INPE)} and Laborato´rio de Biologia Celular e Tecidual,
Universidade do Vale do Paraiba (Univap), Av. Shishima Hifumi
2911, Sao Jose dos Campos, SP 12244-000, Brazil",
title = "Thermodynamic aspects of fibroblastic spreading on diamond-like
carbon films containing titanium dioxide nanoparticles",
journal = "Theoretical Chemistry Accounts",
year = "2011",
volume = "130",
number = "4-6",
pages = "1085--1093",
month = "Dec.",
keywords = "Cell spreading, Cellular viability, Diamond-like carbon,
Hydrophilicity, TiO2 nanoparticles, Work of adhesion.",
abstract = "The combination of low friction, wear resistance, high hardness,
biocompatibility, and chemical inertness makes diamond-like carbon
(DLC) films suitable in numerous applications in biomedical
engineering. The cytotoxicity of DLC films containing TiO2
nanoparticles was practical and theoretically evaluated. The films
were grown on 316L stainless steel substrates from a dispersion of
TiO2 nanopowder in hexane. Raman spectroscopy shows that the
presence of TiO2 increased the graphite-like bonds in the films.
The incorporation of TiO2 nanoparticles into DLC films increases
surface roughness, decreases water contact angle (increased
hydrophilic character), and increases the total free surface
energy due to the higher polar component. As the concentration of
TiO2 increased, the films increased the cell viability (MTT
assay), becoming more thermodynamically favorable to cell
spreading (DFAdh values became more negative). This was evidenced
through the increasing number of projections (philopodia and
lamellipodia), indicating a higher adhesion between the L929 cells
and the films. The practical and theoretical findings of this
study show that the incorporation of TiO2 into DLC films is
effective in enhancing cell viability. These results show the
potential use of DLC and TiO2-DLC films in biomedical
applications.",
doi = "10.1007/s00214-011-1018-5",
url = "http://dx.doi.org/10.1007/s00214-011-1018-5",
issn = "1432-881X",
label = "lattes: 3455204481678421 5 MarcianoMaWaLoTrSoSi:2011:ThAsOf",
language = "en",
targetfile = "marciano1.pdf",
urlaccessdate = "05 maio 2024"
}